Selected Publications (*: equal contribution)

Tan, Z.Y.*, Cai, S.*, Paithankar, S.A., Liu, T., Nie, X., Shi, J., and Gan, L. (2025). Macromolecular and cytological changes in fission yeast G0 nuclei. J. Cell Sci. https://doi.org/10.1242/jcs.263654

Zheng, T., and Cai, S. (2024). Recent technical advances in cellular cryo-electron tomography. Int J Biochem Cell Biol 175, 106648.

https://www.sciencedirect.com/science/article/pii/S1357272524001407

Tan, Z.Y.*, Cai, S.*, Noble, A.J.*, Chen, J.K.*, Shi, J., and Gan, L. (2023). Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ. Elife. 2023 Jul 28;12:RP87672. https://elifesciences.org/reviewed-preprints/87672

Cai, S., Wu, Y., Guillen-Samander, A., Hancock-Cerutti, W., Liu, J., and De Camilli, P. (2022). In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts. Proc Natl Acad Sci U S A 119, e2203769119. https://www.pnas.org/doi/epdf/10.1073/pnas.2203769119

Cai, S., Chen, C., Tan, Z.Y., Huang, Y., Shi, J., and Gan, L. (2018). Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo. Proc Natl Acad Sci U S A 115, 10977-10982. https://www.pnas.org/doi/epdf/10.1073/pnas.1720476115

Cai, S.*,Bock, D.*, Pilhofer, M., and Gan, L. (2018). The in-situ structures of mono-, di-, and trinucleosomes in human heterochromatin. Mol Biol Cell 29, 2450-2457. https://www.molbiolcell.org/doi/10.1091/mbc.E18-05-0331

Cai, S., Song, Y., Chen, C., Shi, J., and Gan, L. (2018). Natural chromatin is heterogeneous and self-associates in vitro. Mol Biol Cell 29, 1652-1663. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080658

Other Publications

Chen, J.K., Liu, T., Cai, S., Ruan, W., Ng, C.T., Shi, J., Surana, U., and Gan, L. (2025). Nanoscale analysis of human G1 and metaphase chromatin in situ. EMBO J., 1–37. https://doi.org/10.1038/s44318-025-00407-2.

Wang, X., Espadas, J., Wu, Y., Cai, S., Ge, J., Shao, L., Roux, A., and De Camilli, P. (2023). Membrane remodeling properties of the Parkinson’s disease protein LRRK2. Proceedings of the National Academy of Sciences 120, e2309698120.

Ma, O.X., Chong, W.G., Lee, J.K.E., Cai, S., Siebert, C.A., Howe, A., Zhang, P., Shi, J., Surana, U., and Gan, L. (2022). Cryo-ET detects bundled triple helices but not ladders in meiotic budding yeast. PLoS ONE 17, e0266035. https://doi.org/10.1371/journal.pone.0266035.

Gan, L., Ng, C.T., Chen, C., and Cai, S. (2019). A collection of yeast cellular electron cryotomography data. GigaScience 8, 873–879. https://doi.org/10.1093/gigascience/giz077.