Selected Publications (*: equal contribution)

Tan, Z.Y.*, Cai, S.*, Paithankar, S.A., Liu, T., Nie, X., Shi, J., and Gan, L. (2025). Macromolecular and cytological changes in fission yeast G0 nuclei. J. Cell Sci. https://doi.org/10.1242/jcs.263654

Zheng, T., and Cai, S. (2024). Recent technical advances in cellular cryo-electron tomography. Int J Biochem Cell Biol 175, 106648.

https://www.sciencedirect.com/science/article/pii/S1357272524001407

Tan, Z.Y.*, Cai, S.*, Noble, A.J.*, Chen, J.K.*, Shi, J., and Gan, L. (2023). Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ. Elife. 2023 Jul 28;12:RP87672. https://elifesciences.org/reviewed-preprints/87672

Cai, S., Wu, Y., Guillen-Samander, A., Hancock-Cerutti, W., Liu, J., and De Camilli, P. (2022). In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts. Proc Natl Acad Sci U S A 119, e2203769119. https://www.pnas.org/doi/epdf/10.1073/pnas.2203769119

Cai, S., Chen, C., Tan, Z.Y., Huang, Y., Shi, J., and Gan, L. (2018). Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo. Proc Natl Acad Sci U S A 115, 10977-10982. https://www.pnas.org/doi/epdf/10.1073/pnas.1720476115

Cai, S.*,Bock, D.*, Pilhofer, M., and Gan, L. (2018). The in-situ structures of mono-, di-, and trinucleosomes in human heterochromatin. Mol Biol Cell 29, 2450-2457. https://www.molbiolcell.org/doi/10.1091/mbc.E18-05-0331

Cai, S., Song, Y., Chen, C., Shi, J., and Gan, L. (2018). Natural chromatin is heterogeneous and self-associates in vitro. Mol Biol Cell 29, 1652-1663. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080658

Other Publications

Wang, X., Xu, P., Bentley-DeSousa, A., Hancock-Cerutti, W., Cai, S., Johnson, B.T., Tonelli, F., Shao, L., Talaia, G., Alessi, D.R., et al. (2025). The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage. Nat. Cell Biol., 1–14. https://doi.org/10.1038/s41556-025-01653-6.

Chen, J.K., Liu, T., Cai, S., Ruan, W., Ng, C.T., Shi, J., Surana, U., and Gan, L. (2025). Nanoscale analysis of human G1 and metaphase chromatin in situ. EMBO J., 1–37. https://doi.org/10.1038/s44318-025-00407-2.

Wang, X., Espadas, J., Wu, Y., Cai, S., Ge, J., Shao, L., Roux, A., and Camilli, P.D. (2023). Membrane remodeling properties of the Parkinson’s disease protein LRRK2. Proc. Natl. Acad. Sci. 120, e2309698120. https://doi.org/10.1073/pnas.2309698120.

Ma, O.X., Chong, W.G., Lee, J.K.E., Cai, S., Siebert, C.A., Howe, A., Zhang, P., Shi, J., Surana, U., and Gan, L. (2022). Cryo-ET detects bundled triple helices but not ladders in meiotic budding yeast. PLoS ONE 17, e0266035. https://doi.org/10.1371/journal.pone.0266035.

Gan, L., Ng, C.T., Chen, C., and Cai, S. (2019). A collection of yeast cellular electron cryotomography data. GigaScience 8, 873–879. https://doi.org/10.1093/gigascience/giz077.