We study the in situ structural and functional mechanisms by which proteins shape and remodel membranes and regulate vesicular trafficking.

To achieve this, we employ state-of-the-art imaging techniques such as cellular cryo-electron tomography (cryo-ET), cryo-focused ion beam (cryo-FIB), cryo-correlated light-electron microscopy, and volume-EM (FIB-SEM). These advanced methods allow us to directly visualize macromolecules and their associated subcellular structures at molecular resolution within cells, tissues and organisms.