Bridge-like lipid transfer proteins, which potentially function in membrane remodeling, are essential for cellular activity and human health. We are interested in understanding the in situ structural mechanisms of these proteins during various cellular activities.
To achieve this, we employ state-of-the-art technologies such as cellular cryo-electron tomography, cryo-focused ion beam, cryo-correlated light-electron microscopy, and volume-EM. These advanced methods allow us to directly visualize these proteins and their associated subcellular structures at molecular resolution within lifelike eukaryotic cells.
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